ABH ANTIGENS ON PLATELETS 995 11 - 1 w U LL 0 w a m 5 5 z W > F a w 1 10 100 FLUORESCENCE INTENSITY
نویسندگان
چکیده
We recently examined a case of refractoriness to HIAmatched, ABO-incompatible platelet transfusions. The transfused platelets that were rapidly cleared from the circulation of the recipient expressed an amount of B antigen more than 20 times that expressed by the blood group B platelets that were successfully transfused to the recipient. These observations led us to conduct enzyme-linked immunosorbent assay (ELISA) and immunoblotting studies of the amount of blood A and B antigens expressed on the surface of platelets from randomly selected donors. The donors were clearly classified, according to the amount of A or B antigen expressed on their platelets, into two phenotypes, the high-expression and low-expression phenotypes. By ELISA, 7% of the examined donors were deter-
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تاریخ انتشار 2003